Transforming Growth Factor-beta Type II Receptor

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.

Also Known As:

Receptor, Transforming Growth Factor-beta Type II; TGF-beta Type II Receptor; TGF-beta Type II Receptors; TGFBR2; TbetaR-II Kinase; Transforming Growth Factor-beta Type II Receptors; Type II TGF-beta Receptor; Type II TGF-beta Receptors; Kinase, TbetaR-II; Receptor, Transforming Growth Factor beta Type II; TGF beta Type II Receptor; TGF beta Type II Receptors; TbetaR II Kinase; Transforming Growth Factor beta Type II Receptor; Transforming Growth Factor beta Type II Receptors; Type II TGF beta Receptor; Type II TGF beta Receptors

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein Serine-Threonine Kinases: 3707
        Transforming Growth Factor-beta Type II Receptor: 899
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Transforming Growth Factor beta Receptors: 838
        Transforming Growth Factor-beta Type II Receptor: 899
      - Immunologic Receptors: 10
        Cytokine Receptors: 1658
        Transforming Growth Factor beta Receptors: 838
        Transforming Growth Factor-beta Type II Receptor: 899
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3707
      - Transforming Growth Factor-beta Type II Receptor: 899

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Disease

Drug/Important Bio-Agent (IBA)